Monthly Archives: August 2017

Generic vs. Branded Anti-Epilepsy Drug, Lamotrigine: Bioequivalence is the Key

Scientists compared three anti-epileptic drugs including one branded Lamotrigine and two lamotrigine-generic drugs and found them to be bioequivalent. Now we know: branded and generic drugs can be substituted with confidence. It is estimated that nearly 80% prescriptions filled in the US are for generic drugs. The US Food and Drug Administration (FDA) requires that…

Does ADHD cause Car Crashes?

Scientists at the Center for Injury Research and Prevention at the Children’s Hospital of Philadelphia asked the question; “what is the association between attention-deficit/ hyperactivity disorder (ADHD) and car crashes involving young adult drivers, and does this vary by sex, licensing age, and/or being prescribed ADHD medication?” Car crashes are the leading cause of death…

Levothyroxine for Subclinical Hypothyroidism Treatment Has No Symptomatic Benefit

In a 2017 study, researchers explored the risks and benefits of levothyroxine for subclinical hypothyroidism treatment in older adults. The findings suggest levothyroxine does not improve hypothyroidism symptoms. Hypothyroidism – underproduction of the thyroid hormone thyroxine and compensatory overproduction of the pituitary hormone which promotes its release, thyroid-stimulating hormone (TSH) –can have profound effects on…

ADHD Medication Leads to Better Performance on Post-Secondary Entrance Test Scores

For those with ADHD, the use of ADHD medication is associated with better performance on higher education entrance tests. This evidence should be considered together with the current list of risks and benefits of ADHD medication to guide clinical practice. Attention-deficit/hyperactivity disorder (ADHD) is common among children and adults alike and can have a negative…

Preventing Endotoxin-Induced Injury in Non Alcoholic Fatty Liver Disease

Metabolic syndrome and non alcoholic fatty liver disease are conditions that are becoming more prevalent due to an increase of fructose and fats in our diets. A new study examines the role of citrulline in preventing endotoxin-induced injury in a rat model of non alcoholic fatty liver disease and finds that citrulline is able to…

Do Proton Pump Inhibitors Increase the Risk of Dementia?

Commonly used for treating acid reflux and stomach ulcers, proton pump inhibitors (PPIs)have recently been questioned as to whether these drugs are also increasing the risk of patients developing dementia and Alzheimer’s Disease (AD). A recent study aimed to further investigate this associated risk and whether the use of PPIs could indeed lead to mild…

Effectiveness of Glucose Management on the Risk of Diabetic Kidney Disease

A meta-analysis combining results across studies assessed outcomes of tight versus standard glucose management on the prevention of onset and progression of end-stage kidney disease (ESKD) in diabetic patients. Study results suggest that diabetic patients who were under stringent glucose control have a comparable risk of kidney failure to those under standard glucose management. Diabetes…

Cervical Precancer Screening Cells With New Biomarker for HPV

Human papillomavirus (HPV) is responsible for causing cervical cancer in many women worldwide, and successful screening programs have been accredited with helping to increase the capacity to identify and treat precancerous and pre-invasive disease. Quantitative methylation of the POU4F3 gene biomarker is a valuable tool for high-grade CIN detection. Cervical cancer, caused by the human…